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KMID : 0616120220530020057
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Korean Journal of Pharmacognosy
2022 Volume.53 No. 2 p.57 ~ p.63
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Secoiridoids, Iridoids and Flavonol Glycosides from Hydrangea paniculata Flowers and their C2C12 Myotube Hypertrophic Activity
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Gao Eun Mei
Kim Chul-Young
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Abstract
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Five secoiridoids (1-3, 5, 10), a iridoid (4) three flavonol glycosides (7-9) and a coumarin (6), were isolated from the flowers of Hydrangea paniculata. Their chemical structures were elucidated as kingiside (1), morroniside (2), sweroside (3), loganin (4), vogeloside (5), umbelliferone (6), quercetin-3-O-sambubioside (7), quercetin-3-O-neohesperidoside (8), kaempferol 3-O-sambubioside (9) and secologanin dimethyl acetal (10), respectively, by spectroscopic analysis. All isolated compounds 1-10 were assessed for their ability to induce C2C12 myotube hypertrophy. Among them, loganin (4) and kaempferol 3-O-sambubioside (9) increase the diameter of C2C12 myotubes. All isolated compounds 1-10 were firstly reported from the flowers of Hydrangea paniculata, and the skeletal muscle hypertrophic activity of 4 and 9 was also reported for the first time.
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KEYWORD
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Hydrangea paniculata Siebold, Secoiridoids, Iridoids, Flavonol glycosides, C2C12 myotube hypertrophy
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